Curcumin and arterial plaques – here´s the latest research you should know about…
You’ve probably heard turmeric being referred to as the golden spice – that’s good
for everything from joint pain to glowing skin…
But what if its active compound, curcumin, may also quietly work to protect your heart from one of the most dangerous threats: arterial plaque?
Help transform your health, and feel energised…
Studies show that curcumin is a potent antioxidant that can help neutralise free radicals due to its chemical structure.
Curcumin also stimulates other antioxidants in the body.
This nutrient also helps reduce inflammation in the body. Chronic inflammation is both a known culprit and a symptom of many illneses.
It could be your ally to prevent metabolic syndrome, arthritis, anxiety, and high cholesterol.
And it could help you feel healthier…
Curcumin and arterial plaque…
Arterial plaque is a sticky, fatty buildup that clings to the walls of arteries…
It’s made up of cholesterol, calcium, cellular waste, and fibrin.
Over time, this buildup can narrow the arteries – a condition known as atherosclerosis – and restrict blood flow…
That’s when things get dangerous: heart attacks, strokes, and peripheral artery disease are all potential consequences.
So, preventing or reversing plaque buildup is a major goal in cardiovascular medicine.
A 2022 review published in Cells found that curcumin significantly reduces oxidative stress and inflammatory markers – two key drivers of plaque formation.
The study emphasised curcumin’s ability to modulate mitochondrial function and reduce reactive oxygen species (ROS), which damage blood vessels and promote plaque buildup.
A 2024 review published in Drug Design, Development and Therapy highlighted curcumin’s ability to inhibit foam cell formation and reduce vascular smooth muscle cell proliferation, both of which are critical steps in plaque development.
A systematic review of clinical trials published in 2021 found that curcumin supplementation led to improvements in LDL cholesterol, triglycerides, and total cholesterol in more than two-thirds of the studies analysed…
Since high LDL is a major contributor to plaque buildup, this effect is particularly promising.
Healthy endothelium (the inner lining of blood vessels) is essential for preventing plaque formation…
Curcumin has been shown to improve nitric oxide availability, reduce vascular inflammation, and protect endothelial cells from damage – all of which help maintain smooth, plaque-free arteries.
Keep reading…
Curcumin can be a powerful ally against heart disease…
While curcumin isn’t a substitute for exercise or a heart-healthy diet, it may be a valuable resource to help prevent atherosclerosis or its progression.
Curcumin’s anti-atherosclerotic effects are driven by a multi-pronged series of mechanisms:
* Suppresses NF-κB and TNF-α: These inflammatory pathways promote plaque formation.
* Inhibits lipid peroxidation: Prevents oxidative damage to LDL cholesterol.
* Modulates gene expression: Downregulates genes involved in inflammation and cell proliferation.
* Improves insulin sensitivity: Indirectly reduces cardiovascular risk by managing metabolic syndrome.
References:
https://www.mdpi.com/2073-4409/11/3/342
https://pubmed.ncbi.nlm.nih.gov/34331690/
https://pubmed.ncbi.nlm.nih.gov/31577640/
https://pubmed.ncbi.nlm.nih.gov/30716389/
https://pubmed.ncbi.nlm.nih.gov/28274852/
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